Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80477
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
2890±297 nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80477
Synonyms:
1-O-tert-butyl 2-O-[2-oxo-2-(4-phenylphenyl)ethyl] 4-hydroxypyrrolidine-1,2-dicarboxylate | 4-hydroxypyrrolidine-1,2-dicarboxylic acid O1-tert-butyl ester O2-[2-keto-2-(4-phenylphenyl)ethyl] ester | 4-hydroxypyrrolidine-1,2-dicarboxylic acid O1-tert-butyl ester O2-[2-oxo-2-(4-phenylphenyl)ethyl] ester | MLS000856402 | O1-tert-butyl O2-[2-oxidanylidene-2-(4-phenylphenyl)ethyl] 4-oxidanylpyrrolidine-1,2-dicarboxylate | SMR000279347 | cid_2884840
Type:
Small organic molecule
Emp. Form.:
C24H27NO6
Mol. Mass.:
425.4743
SMILES:
CC(C)(C)OC(=O)N1CC(O)CC1C(=O)OCC(=O)c1ccc(cc1)-c1ccccc1
Structure:
