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Target
Cysteine protease ATG4B
Ligand
BDBM51963
Substrate
n/a
Meas. Tech.
Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B.
IC50
8860±n/a nM
Citation
 PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. PubChem Bioassay (2011)[AID] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM51963
Synonyms:
MLS000557398 | N-[5-(2-Fluoro-benzylsulfanylmethyl)-[1,3,4]thiadiazol-2-yl]-2,2-dimethyl-propionamide | N-[5-[(2-fluorophenyl)methylsulfanylmethyl]-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propanamide | N-[5-[(2-fluorophenyl)methylsulfanylmethyl]-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide | N-[5-[[(2-fluorobenzyl)thio]methyl]-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionamide | N-[5-[[(2-fluorophenyl)methylthio]methyl]-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide | SMR000148315 | cid_945654
Type:
Small organic molecule
Emp. Form.:
C15H18FN3OS2
Mol. Mass.:
339.451
SMILES:
CC(C)(C)C(=O)Nc1nnc(CSCc2ccccc2F)s1
Structure:
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