Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM51272
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli (strain K12)
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM51272
Synonyms:
(2E)-1-acetyl-2-[(4-chloroanilino)methylene]pseudoindoxyl | (2E)-1-acetyl-2-[(4-chloroanilino)methylidene]-3-indolone | (2E)-1-acetyl-2-[(4-chloroanilino)methylidene]indol-3-one | (2E)-2-[[(4-chlorophenyl)amino]methylidene]-1-ethanoyl-indol-3-one | 1-Acetyl-2-[1-(4-chloro-phenylamino)-meth-(Z)-ylidene]-1,2-dihydro-indol-3-one | MLS000776700 | SMR000413099 | cid_5552294
Type:
Small organic molecule
Emp. Form.:
C17H13ClN2O2
Mol. Mass.:
312.75
SMILES:
CC(=O)n1c(C=Nc2ccc(Cl)cc2)c(O)c2ccccc12 |w:6.6|
Structure:
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