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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50261445
Substrate
n/a
Meas. Tech.
ChEBML_1696020
EC50
248±n/a nM
Citation
 Bewley, BR; Spearing, PK; Weiner, RL; Luscombe, VB; Zhan, X; Chang, S; Cho, HP; Rodriguez, AL; Niswender, CM; Conn, PJ; Bridges, TM; Engers, DW; Lindsley, CW Discovery of a novel, CNS penetrant M Bioorg Med Chem Lett 27:4274-4279 (2017) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50261445
Synonyms:
CHEMBL4075391
Type:
Small organic molecule
Emp. Form.:
C22H20FN5O3S
Mol. Mass.:
453.489
SMILES:
NS(=O)(=O)c1ccc(NC(=O)C2CCN(CC2)c2c(cnc3ccc(F)cc23)C#N)cc1
Structure:
Search PDB for entries with ligand similarity: