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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM309529
Substrate
n/a
Meas. Tech.
ChEMBL_1728184 (CHEMBL4143462)
IC50
94±n/a nM
Citation
 Weng, T; Qiu, X; Wang, J; Li, Z; Bian, J Recent discovery of indoleamine-2,3-dioxygenase 1 inhibitors targeting cancer immunotherapy. Eur J Med Chem 143:656-669 (2018) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_MOUSE | IDO-1 | Ido | Ido1 | Indo | Indoleamine-pyrrole 2,3-dioxygenase
Type:
PROTEIN
Mol. Mass.:
45639.39
Organism:
Mouse
Description:
ChEMBL_1452149
Residue:
407
Sequence:
MALSKISPTEGSRRILEDHHIDEDVGFALPHPLVELPDAYSPWVLVARNLPVLIENGQLREEVEKLPTLSTDGLRGHRLQRLAHLALGYITMAYVWNRGDDDVRKVLPRNIAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLLVEIAASPAIKAIPTVSSAVERQDLKALEKALHDIATSLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKCSSKLPEGLLYEGVWDTPKMFSGGSAGQSSIFQSLDVLLGIKHEAGKESPAEFLQEMREYMPPAHRNFLFFLESAPPVREFVISRHNEDLTKAYNECVNGLVSVRKFHLAIVDTYIMKPSKKKPTDGDKSEEPSNVESRGTGGTNPMTFLRSVKDTTEKALLSWP
  
Inhibitor
Name:
BDBM309529
Synonyms:
3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione | US10945994, Compound 1 | US9603836, Compound 1 | US9603836, Compound 1a | US9949951, 1a
Type:
Small organic molecule
Emp. Form.:
C12H9FN2O2
Mol. Mass.:
232.2105
SMILES:
Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1
Structure:
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