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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM45881
Substrate
n/a
Meas. Tech.
ChEMBL_1751742 (CHEMBL4186502)
IC50
543±n/a nM
Citation
 Pinkerton, AB; Sergienko, E; Bravo, Y; Dahl, R; Ma, CT; Sun, Q; Jackson, MR; Cosford, NDP; Millán, JL Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett 28:31-34 (2018) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM45881
Synonyms:
5-bromanyl-2-methoxy-N-pyridin-3-yl-benzenesulfonamide | 5-bromo-2-methoxy-N-(3-pyridinyl)benzenesulfonamide | 5-bromo-2-methoxy-N-(3-pyridyl)benzenesulfonamide | 5-bromo-2-methoxy-N-pyridin-3-ylbenzenesulfonamide | MLS-0090851.0001 | US10370333, Example I-3 | cid_839345
Type:
Small organic molecule
Emp. Form.:
C12H11BrN2O3S
Mol. Mass.:
343.196
SMILES:
COc1ccc(Br)cc1S(=O)(=O)Nc1cccnc1
Structure:
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