Reaction Details Report a problem with these data
Target
Similar to alpha-tubulin isoform 1
Ligand
BDBM50059972
Substrate
n/a
Meas. Tech.
ChEMBL_211334 (CHEMBL820777)
IC50
930±n/a nM
Citation
 Chen, K; Kuo, SC; Hsieh, MC; Mauger, A; Lin, CM; Hamel, E; Lee, KH Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization. J Med Chem 40:3049-56 (1997) [PubMed]  Article 
Target
Name:
Similar to alpha-tubulin isoform 1
Synonyms:
Similar to alpha-tubulin isoform 1
Type:
PROTEIN
Mol. Mass.:
10383.05
Organism:
Bos taurus
Description:
ChEMBL_104716
Residue:
99
Sequence:
CVSASPSTLARLVSRSAMPAGSSTAWNTAFSPMARCQVTKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRSSSTLSSSSQAKKMP
  
Inhibitor
Name:
BDBM50059972
Synonyms:
5-Methyl-2-naphthalen-1-yl-1H-[1,8]naphthyridin-4-one | CHEMBL51998
Type:
Small organic molecule
Emp. Form.:
C19H14N2O
Mol. Mass.:
286.3273
SMILES:
Cc1ccnc2nc(cc(O)c12)-c1cccc2ccccc12
Structure:
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