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Target
Presenilin-1
Ligand
BDBM50484301
Substrate
n/a
Meas. Tech.
ChEMBL_772762 (CHEMBL1837501)
IC50
29±n/a nM
Citation
 Aubele, DL; Truong, AP; Dressen, DB; Probst, GD; Bowers, S; Mattson, MN; Semko, CM; Sun, M; Garofalo, AW; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Goldbach, E; Quinn, KP; Sauer, JM; Brigham, EF; Wallace, W; Nguyen, L; Bova, MP; Hemphill, SS; Basi, G Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent ?-secretase inhibitors. Bioorg Med Chem Lett 21:5791-4 (2011) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50484301
Synonyms:
CHEMBL1837053
Type:
Small organic molecule
Emp. Form.:
C24H23F3N4O3S
Mol. Mass.:
504.525
SMILES:
CC(=O)Nc1cccc(c1)C1CC2Cc3[nH]ncc3C(C1)N2S(=O)(=O)c1ccc(cc1)C(F)(F)F |THB:22:21:11.20.10:13.18.14|
Structure:
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