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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50537553
Substrate
n/a
Meas. Tech.
ChEMBL_1969954 (CHEMBL4602772)
IC50
2300±n/a nM
Citation
 Xu, M; Wang, SL; Zhu, L; Wu, PY; Dai, WB; Rakesh, KP Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3? inhibitors: A critical review. Eur J Med Chem 164:448-470 (2019) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50537553
Synonyms:
CHEMBL4646033
Type:
Small organic molecule
Emp. Form.:
C28H30F3NO11
Mol. Mass.:
613.5331
SMILES:
COc1ccc(cc1OC)-c1cc(=O)c2c(OC)c([C@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(=O)N[C@H](C)C(F)(F)F)c(OC)cc2o1 |r|
Structure:
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