Reaction Details Report a problem with these data
Target
Deoxyhypusine synthase
Ligand
BDBM50032513
Substrate
n/a
Meas. Tech.
ChEMBL_53735 (CHEMBL663660)
IC50
83000±n/a nM
Citation
 Lee, YB; Park, MH; Folk, JE Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity. J Med Chem 38:3053-61 (1995) [PubMed]  Article 
Target
Name:
Deoxyhypusine synthase
Synonyms:
DHYS_RAT | Dhps
Type:
PROTEIN
Mol. Mass.:
40696.63
Organism:
Rattus norvegicus
Description:
ChEMBL_53735
Residue:
369
Sequence:
MEGTPSGAAPSSALAAVLKHSSALPPESAQVQGYDFNRGVDYHALLEAYGTTGFQATNFGRAVQQVNAMIEKKLEPLAVDEDHHEDLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNDNYCKFEDWLMPILDQMVQEQNTEGVKWTPSKMISRLGKEINNPESVYYWAHKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINMQAIFAKRTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKADAFRAEKNED
  
Inhibitor
Name:
BDBM50032513
Synonyms:
3-(3-Amino-propylsulfanyl)-propylamine | CHEMBL29299
Type:
Small organic molecule
Emp. Form.:
C6H16N2S
Mol. Mass.:
148.27
SMILES:
NCCCSCCCN
Structure:
Search PDB for entries with ligand similarity: