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Target
Platelet-activating factor receptor
Ligand
BDBM50041922
Substrate
n/a
Meas. Tech.
ChEBML_151717
IC50
89000±n/a nM
Citation
 Houlihan, WJ; Cheon, SH; Parrino, VA; Handley, DA; Larson, DA Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists. J Med Chem 36:3098-102 (1993) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Human
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM50041922
Synonyms:
5-{4-[2-(3,4,5-Trimethoxy-phenyl)-ethyl]-phenyl}-imidazo[2,1-a]isoquinoline | CHEMBL320577
Type:
Small organic molecule
Emp. Form.:
C28H26N2O3
Mol. Mass.:
438.5176
SMILES:
COc1cc(CCc2ccc(cc2)-c2cc3ccccc3c3nccn23)cc(OC)c1OC
Structure:
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