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Target
Casein kinase I isoform delta
Ligand
BDBM50508988
Substrate
n/a
Meas. Tech.
ChEMBL_1836638 (CHEMBL4336771)
IC50
13±n/a nM
Citation
 Qiao, Y; Chen, T; Yang, H; Chen, Y; Lin, H; Qu, W; Feng, F; Liu, W; Guo, Q; Liu, Z; Sun, H Small molecule modulators targeting protein kinase CK1 and CK2. Eur J Med Chem 181:0 (2019) [PubMed]  Article 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta)
Type:
Enzyme
Mol. Mass.:
47356.76
Organism:
Homo sapiens (Human)
Description:
P48730
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM50508988
Synonyms:
CHEMBL4445830
Type:
Small organic molecule
Emp. Form.:
C18H15FN4O
Mol. Mass.:
322.3363
SMILES:
CN1Cc2nccc(-c3cn(C)nc3-c3ccc(F)cc3)c2C1=O
Structure:
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