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Target
Genome polyprotein
Ligand
BDBM50515220
Substrate
n/a
Meas. Tech.
ChEMBL_1860167 (CHEMBL4361023)
EC50
260±n/a nM
Citation
 Yoon, JS; Kim, G; Jarhad, DB; Kim, HR; Shin, YS; Qu, S; Sahu, PK; Kim, HO; Lee, HW; Wang, SB; Kong, YJ; Chang, TS; Ogando, NS; Kovacikova, K; Snijder, EJ; Posthuma, CC; van Hemert, MJ; Jeong, LS Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues. J Med Chem 62:6346-6362 (2019) [PubMed]  Article 
Target
Name:
Genome polyprotein
Synonyms:
NS5
Type:
PROTEIN
Mol. Mass.:
39098.80
Organism:
Zika virus
Description:
ChEMBL_119669
Residue:
340
Sequence:
EFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWMGRENSGGGVEGLGLQRLGYVLEEMSRIPGGRMYADDTAGWDTRISRFDLENEALITNQMEKGHRALALAIIKYTYQNKVVKVLRPAEKGKTVMDIISRQDQRGSGQVVTYALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRRSEKVTNWLQSNGWDRLKRMAVSGDDCVVKPIDDRFAHALRFLNDMGKVRKDTQEWKPSTGWDNWEEVPFCSHHFNKLHLKDGRSIVVPCRHQDELIGRARVSPGAGWSIRETACLAKSYAQMWQLLYFHRRDLRLMANAICSSVPVDWVPTGRTTWSIHGKGE
  
Inhibitor
Name:
BDBM50515220
Synonyms:
CHEMBL4544781
Type:
Small organic molecule
Emp. Form.:
C11H13F2N5O3
Mol. Mass.:
301.2494
SMILES:
Nc1ncnc2n(cnc12)[C@H]1[C@H](O)[C@H](O)[C@@H](CO)C1(F)F |r|
Structure:
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