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Target
Adenosylhomocysteinase
Ligand
BDBM50515225
Substrate
n/a
Meas. Tech.
ChEMBL_1860162 (CHEMBL4361018)
IC50
>100000±n/a nM
Citation
 Yoon, JS; Kim, G; Jarhad, DB; Kim, HR; Shin, YS; Qu, S; Sahu, PK; Kim, HO; Lee, HW; Wang, SB; Kong, YJ; Chang, TS; Ogando, NS; Kovacikova, K; Snijder, EJ; Posthuma, CC; van Hemert, MJ; Jeong, LS Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues. J Med Chem 62:6346-6362 (2019) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50515225
Synonyms:
CHEMBL4464364
Type:
Small organic molecule
Emp. Form.:
C10H13F2N3O4
Mol. Mass.:
277.2247
SMILES:
Nc1ccn([C@H]2[C@H](O)[C@H](O)[C@@H](CO)C2(F)F)c(=O)n1 |r|
Structure:
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