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Target
Genome polyprotein
Ligand
BDBM50088426
Substrate
n/a
Meas. Tech.
ChEMBL_1860167 (CHEMBL4361023)
EC50
640±n/a nM
Citation
Yoon, JS; Kim, G; Jarhad, DB; Kim, HR; Shin, YS; Qu, S; Sahu, PK; Kim, HO; Lee, HW; Wang, SB; Kong, YJ; Chang, TS; Ogando, NS; Kovacikova, K; Snijder, EJ; Posthuma, CC; van Hemert, MJ; Jeong, LS Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues. J Med Chem 62:6346-6362 (2019) [PubMed] Article
More Info.:
Target
Name:
Genome polyprotein
Synonyms:
NS5
Type:
PROTEIN
Mol. Mass.:
39098.80
Organism:
Zika virus
Description:
ChEMBL_119669
Residue:
340
Sequence:
EFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWMGRENSGGGVEGLGLQRLGYVLEEMSRIPGGRMYADDTAGWDTRISRFDLENEALITNQMEKGHRALALAIIKYTYQNKVVKVLRPAEKGKTVMDIISRQDQRGSGQVVTYALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRRSEKVTNWLQSNGWDRLKRMAVSGDDCVVKPIDDRFAHALRFLNDMGKVRKDTQEWKPSTGWDNWEEVPFCSHHFNKLHLKDGRSIVVPCRHQDELIGRARVSPGAGWSIRETACLAKSYAQMWQLLYFHRRDLRLMANAICSSVPVDWVPTGRTTWSIHGKGE
Inhibitor
Name:
BDBM50088426
Synonyms:
(1R,2S,3R,5R)-3-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol | 3-(6-Amino-purin-9-yl)-5-hydroxymethyl-cyclopentane-1,2-diol | CHEMBL49935
Type:
Small organic molecule
Emp. Form.:
C11H15N5O3
Mol. Mass.:
265.2685
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O