Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50520102
Substrate
n/a
Meas. Tech.
ChEMBL_1879038 (CHEMBL4380432)
IC50
>10000±n/a nM
Citation
 Yang, JJ; Yu, WW; Hu, LL; Liu, WJ; Lin, XH; Wang, W; Zhang, Q; Wang, PL; Tang, SW; Wang, X; Liu, M; Lu, W; Zhang, HK Discovery and Characterization of 1 J Med Chem 63:569-590 (2020) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Homo sapiens (Human)
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM50520102
Synonyms:
CHEMBL4453648
Type:
Small organic molecule
Emp. Form.:
C25H23F3N4O3
Mol. Mass.:
484.4703
SMILES:
C[C@H](NC(=O)c1c(nnn1Cc1ccc(cc1)C(F)(F)F)C1=CCCC1)c1ccc(cc1)C(O)=O |r,t:23|
Structure:
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