Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM309529
Substrate
n/a
Meas. Tech.
ChEMBL_1880242 (CHEMBL4381636)
IC50
410±n/a nM
Citation
 Peng, YH; Liao, FY; Tseng, CT; Kuppusamy, R; Li, AS; Chen, CH; Fan, YS; Wang, SY; Wu, MH; Hsueh, CC; Chang, JY; Lee, LC; Shih, C; Shia, KS; Yeh, TK; Hung, MS; Kuo, CC; Song, JS; Wu, SY; Ueng, SH Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors. J Med Chem 63:1642-1659 (2020) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Human
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM309529
Synonyms:
3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione | US10945994, Compound 1 | US9603836, Compound 1 | US9603836, Compound 1a | US9949951, 1a
Type:
Small organic molecule
Emp. Form.:
C12H9FN2O2
Mol. Mass.:
232.2105
SMILES:
Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1
Structure:
Search PDB for entries with ligand similarity: