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Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50077347
Substrate
n/a
Meas. Tech.
ChEMBL_32264 (CHEMBL645598)
IC50
48820.0±n/a nM
Citation
 Costantino, L; Rastelli, G; Gamberini, MC; Giovannoni, MP; Dal Piaz, V; Vianello, P; Barlocco, D Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors. J Med Chem 42:1894-900 (1999) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50077347
Synonyms:
(5-Benzylamino-6-oxo-3-phenyl-6H-pyridazin-1-yl)-acetic acid | CHEMBL56416
Type:
Small organic molecule
Emp. Form.:
C19H17N3O3
Mol. Mass.:
335.3566
SMILES:
OC(=O)Cn1nc(cc(NCc2ccccc2)c1=O)-c1ccccc1
Structure:
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