Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50524264
Substrate
n/a
Meas. Tech.
ChEMBL_1892555 (CHEMBL4394476)
EC50
5.0±n/a nM
Citation
 Shen, Y; McCorvy, JD; Martini, ML; Rodriguiz, RM; Pogorelov, VM; Ward, KM; Wetsel, WC; Liu, J; Roth, BL; Jin, J D J Med Chem 62:4755-4771 (2019) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50524264
Synonyms:
CHEMBL4446533
Type:
Small organic molecule
Emp. Form.:
C20H30ClN3O
Mol. Mass.:
363.925
SMILES:
CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCc3ccc(Cl)cc3C2)CC1 |r,wU:6.5,wD:9.9,(21.28,-16.73,;20.52,-15.39,;21.3,-14.07,;18.98,-15.38,;18.22,-14.04,;18.2,-16.71,;16.66,-16.7,;15.88,-18.03,;14.34,-18.02,;13.58,-16.67,;12.04,-16.67,;11.28,-15.33,;9.74,-15.33,;8.97,-13.99,;7.42,-13.98,;6.66,-15.32,;5.13,-15.33,;4.37,-16.66,;5.15,-17.98,;4.38,-19.32,;6.67,-17.98,;7.43,-16.65,;8.96,-16.66,;14.35,-15.35,;15.9,-15.36,)|
Structure:
Search PDB for entries with ligand similarity: