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Target
Integrase
Ligand
BDBM50079910
Substrate
n/a
Meas. Tech.
ChEMBL_90899 (CHEMBL699512)
IC50
>1000000±n/a nM
Citation
 Neamati, N; Turpin, JA; Winslow, HE; Christensen, JL; Williamson, K; Orr, A; Rice, WG; Pommier, Y; Garofalo, A; Brizzi, A; Campiani, G; Fiorini, I; Nacci, V Thiazolothiazepine inhibitors of HIV-1 integrase. J Med Chem 42:3334-41 (1999) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50079910
Synonyms:
Acetic acid 4-oxo-2,3,10,10a-tetrahydro-1H,4H-9-thia-3a-aza-benzo[f]azulen-10-yl ester | CHEMBL112368
Type:
Small organic molecule
Emp. Form.:
C14H15NO3S
Mol. Mass.:
277.339
SMILES:
CC(=O)OC1Sc2ccccc2C(=O)N2CCCC12
Structure:
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