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Target
Folate receptor alpha
Ligand
BDBM50529285
Substrate
n/a
Meas. Tech.
ChEMBL_1908223 (CHEMBL4410581)
IC50
1.8±n/a nM
Citation
Xiang, W; Dekhne, A; Doshi, A; O'Connor, C; Hou, Z; Matherly, LH; Gangjee, A Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor ? and inhibition of de novo purine nucleotide biosynthesis. Bioorg Med Chem 27:0 (2019) [PubMed] Article
More Info.:
Target
Name:
Folate receptor alpha
Synonyms:
Adult folate-binding protein | FBP | FOLR | FOLR1 | FOLR1_HUMAN | FR-alpha | Folate receptor 1 | Folate receptor, adult | KB cells FBP | Ovarian tumor-associated antigen MOv18
Type:
PROTEIN
Mol. Mass.:
29827.41
Organism:
Human
Description:
ChEMBL_1469596
Residue:
257
Sequence:
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS