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Target
Dihydrofolate reductase
Ligand
BDBM18512
Substrate
n/a
Meas. Tech.
ChEMBL_1908254 (CHEMBL4410612)
Ki
28±n/a nM
Citation
Saepua, S; Sadorn, K; Vanichtanankul, J; Anukunwithaya, T; Rattanajak, R; Vitsupakorn, D; Kamchonwongpaisan, S; Yuthavong, Y; Thongpanchang, C 6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum. Bioorg Med Chem 27:0 (2019) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Human
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND