Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50531883
Substrate
n/a
Meas. Tech.
ChEMBL_1921296 (CHEMBL4424141)
EC50
150±n/a nM
Citation
 Kong, D; Guo, S; Yang, Y; Guo, B; Xie, X; Hu, W Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine. Bioorg Med Chem Lett 29:848-852 (2019) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50531883
Synonyms:
CHEMBL4459626
Type:
Small organic molecule
Emp. Form.:
C28H23NO5
Mol. Mass.:
453.4859
SMILES:
CC#C[C@@H](CC(O)=O)c1ccc(OC[C@H]2COc3ccc(cc3O2)-c2ccc(cc2)C#N)cc1 |r|
Structure:
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