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Target
Protein arginine N-methyltransferase 6
Ligand
BDBM50532859
Substrate
n/a
Meas. Tech.
ChEMBL_1924031 (CHEMBL4426987)
IC50
5200±n/a nM
Citation
 Ferreira de Freitas, R; Eram, MS; Smil, D; Szewczyk, MM; Kennedy, S; Brown, PJ; Santhakumar, V; Barsyte-Lovejoy, D; Arrowsmith, CH; Vedadi, M; Schapira, M Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. J Med Chem 59:6838-47 (2016) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 6
Synonyms:
ANM6_HUMAN | HRMT1L6 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 | Histone-arginine N-methyltransferase PRMT6 | PRMT6 | Protein arginine methyltransferase 6 (PRMT6)
Type:
Protein
Mol. Mass.:
41928.48
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
375
Sequence:
MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED
  
Inhibitor
Name:
BDBM50532859
Synonyms:
CHEMBL4436627
Type:
Small organic molecule
Emp. Form.:
C19H25ClN2O2
Mol. Mass.:
348.867
SMILES:
Cl.C[C@H](N)C(=O)NCc1ccc(Oc2cc(C)cc(C)c2)c(C)c1 |r|
Structure:
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