Reaction Details Report a problem with these data
Target
Proteinase-activated receptor 4
Ligand
BDBM50024254
Substrate
n/a
Meas. Tech.
ChEMBL_1933890 (CHEMBL4479542)
IC50
130±n/a nM
Citation
 Temple, KJ; Duvernay, MT; Young, SE; Wen, W; Wu, W; Maeng, JG; Blobaum, AL; Stauffer, SR; Hamm, HE; Lindsley, CW Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against ?-Thrombin. J Med Chem 59:7690-5 (2016) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 4
Synonyms:
Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:
Protein
Mol. Mass.:
41145.16
Organism:
Homo sapiens (Human)
Description:
Q96RI0
Residue:
385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
  
Inhibitor
Name:
BDBM50024254
Synonyms:
CHEMBL125021
Type:
Small organic molecule
Emp. Form.:
C23H20N2O2
Mol. Mass.:
356.4171
SMILES:
CCOC(=O)c1ccc(cc1)-c1nn(Cc2ccccc2)c2ccccc12
Structure:
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