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Target
Vascular cell adhesion protein 1
Ligand
BDBM50098480
Substrate
n/a
Meas. Tech.
ChEMBL_213817 (CHEMBL815900)
IC50
>4000±n/a nM
Citation
 Stewart, AO; Bhatia, PA; McCarty, CM; Patel, MV; Staeger, MA; Arendsen, DL; Gunawardana, IW; Melcher, LM; Zhu, GD; Boyd, SA; Fry, DG; Cool, BL; Kifle, L; Lartey, K; Marsh, KC; Kempf-Grote, AJ; Kilgannon, P; Wisdom, W; Meyer, J; Gallatin, WM; Okasinski, GF Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. J Med Chem 44:988-1002 (2001) [PubMed]  Article 
Target
Name:
Vascular cell adhesion protein 1
Synonyms:
CD106 antigen | INCAM-100 | VCAM-1 | VCAM1 | VCAM1_HUMAN | Vascular cell adhesion protein 1 | Vascular cell adhesion protein 1 (VCAM-1) | Vascular cell adhesion protein 1 precursor
Type:
Other Protein Type
Mol. Mass.:
81259.16
Organism:
Human
Description:
P19320
Residue:
739
Sequence:
MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYSLVEAQKSKV
  
Inhibitor
Name:
BDBM50098480
Synonyms:
4-(4-Bromo-phenylsulfanyl)-thieno[2,3-c]pyridine-2-carboxylic acid amide | CHEMBL266198
Type:
Small organic molecule
Emp. Form.:
C14H9BrN2OS2
Mol. Mass.:
365.268
SMILES:
NC(=O)c1cc2c(Sc3ccc(Br)cc3)cncc2s1
Structure:
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