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Target
Platelet-activating factor acetylhydrolase
Ligand
BDBM50102150
Substrate
n/a
Meas. Tech.
ChEBML_156211
IC50
34±n/a nM
Citation
 Bloomer, JC; Boyd, HF; Hickey, DM; Ife, RJ; Leach, CA; Macphee, CH; Milliner, KJ; Pinto, IL; Rawlings, DA; Smith, SA; Stansfield, IG; Stanway, SJ; Taylor, MA; Theobald, CJ; Whittaker, CM 1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A(2). Bioorg Med Chem Lett 11:1925-9 (2001) [PubMed]  Article 
Target
Name:
Platelet-activating factor acetylhydrolase
Synonyms:
1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase
Type:
PROTEIN
Mol. Mass.:
50084.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_156212
Residue:
441
Sequence:
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN
  
Inhibitor
Name:
BDBM50102150
Synonyms:
5-(2-tert-Butyl-pyrimidin-5-ylmethyl)-1-{2-[4-(4-chloro-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-2-(4-fluoro-benzylsulfanyl)-1H-pyrimidin-4-one | CHEMBL57353
Type:
Small organic molecule
Emp. Form.:
C32H34ClFN6O2S
Mol. Mass.:
621.168
SMILES:
CC(C)(C)c1ncc(Cc2cn(CC(=O)N3CCN(CC3)c3ccc(Cl)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1
Structure:
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