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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50022184
Substrate
n/a
Meas. Tech.
ChEMBL_2051296 (CHEMBL4705995)
IC50
11210±n/a nM
Citation
 Xia, YL; Wang, JJ; Li, SY; Liu, Y; Gonzalez, FJ; Wang, P; Ge, GB Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. Bioorg Med Chem 29:0 (2021) [PubMed]  Article 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50022184
Synonyms:
7,8-Dihydroxy-4-methyl-2H-chromen-2-one (3) | 7,8-Dihydroxy-4-methyl-chromen-2-one | 7,8-dihydroxy-4-methyl-2H-chromen-2-one | 7,8-dihydroxy-4-methylcoumarin | CHEMBL276618
Type:
Small organic molecule
Emp. Form.:
C10H8O4
Mol. Mass.:
192.1681
SMILES:
Cc1cc(=O)oc2c(O)c(O)ccc12
Structure:
Search PDB for entries with ligand similarity: