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Target
B-cell receptor CD22
Ligand
BDBM50556311
Substrate
n/a
Meas. Tech.
ChEMBL_2055847 (CHEMBL4710848)
Kd
860±n/a nM
Citation
 Abdu-Allah, HHM; Wu, SC; Lin, CH; Tseng, YY Design, synthesis and molecular docking study of ?-triazolylsialosides as non-hydrolyzable and potent CD22 ligands. Eur J Med Chem 208:0 (2020) [PubMed]  Article 
Target
Name:
B-cell receptor CD22
Synonyms:
CD22 | CD22_HUMAN | SIGLEC2
Type:
PROTEIN
Mol. Mass.:
95348.60
Organism:
Homo sapiens (Human)
Description:
ChEMBL_727026
Residue:
847
Sequence:
MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH
  
Inhibitor
Name:
BDBM50556311
Synonyms:
CHEMBL4783164
Type:
Small organic molecule
Emp. Form.:
C34H42N5NaO11
Mol. Mass.:
719.7139
SMILES:
[Na;v0+].[H][C@]1([#8][C@]([#6]-[#6@H](-[#8])-[#6@H]1-[#7]-[#6](=O)-[#6]-[#8])([#6](-[#8-])=O)n1cc(-[#8]-[#6]-[#6]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)nn1)[#6@H](-[#8])-[#6@H](-[#8])-[#6]-[#7]-[#6](=O)-[#6]-c1ccc(cc1)-c1ccc(-[#8])cc1 |r|
Structure:
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