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Target
Protein-tyrosine kinase 6
Ligand
BDBM50558112
Substrate
n/a
Meas. Tech.
ChEMBL_2061794 (CHEMBL4717047)
IC50
63±n/a nM
Citation
 Liu, J; Guiadeen, D; Krikorian, A; Gao, X; Wang, J; Boga, SB; Alhassan, AB; Yu, Y; Vaccaro, H; Liu, S; Yang, C; Wu, H; Cooper, A; de Man, J; Kaptein, A; Maloney, K; Hornak, V; Gao, YD; Fischmann, TO; Raaijmakers, H; Vu-Pham, D; Presland, J; Mansueto, M; Xu, Z; Leccese, E; Zhang-Hoover, J; Knemeyer, I; Garlisi, CG; Bays, N; Stivers, P; Brandish, PE; Hicks, A; Kim, R; Kozlowski, JA Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis. ACS Med Chem Lett 7:198-203 (2016) [PubMed]  Article 
Target
Name:
Protein-tyrosine kinase 6
Synonyms:
BRK | Breast tumor kinase | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | PTK6 | PTK6_HUMAN | Protein-tyrosine kinase 6 (BRK) | Tyrosine Kinase BRK | Tyrosine-protein kinase 6 | Tyrosine-protein kinase BRK
Type:
Tyrosine-protein kinase
Mol. Mass.:
51839.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
451
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT
  
Inhibitor
Name:
BDBM50558112
Synonyms:
CHEMBL4799627
Type:
Small organic molecule
Emp. Form.:
C29H27F4N7O3
Mol. Mass.:
597.5634
SMILES:
CC1(COC1)C(=O)N1CCC[C@H](C1)c1nc(-c2ccc(cc2F)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12 |r|
Structure:
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