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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Ligand
BDBM50558596
Substrate
n/a
Meas. Tech.
ChEMBL_2063959 (CHEMBL4719212)
IC50
64±n/a nM
Citation
 Balasubramanian, G; Narayanan, S; Andiappan, L; Sappanimuthu, T; Thirunavukkarasu, S; Sundaram, S; Natarajan, S; Sivaraman, N; Rajagopal, S; Nazumudeen, FAA; Saxena, S; Vishwakarma, SL; Narayanan, S; Sharma, GVR; Srinivasan, CV; Kilambi, N In vivo effective dibenzo[b,d]furan-1-yl-thiazoles as novel PDE-4 inhibitors. Bioorg Med Chem 24:5702-5716 (2016) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B)
Type:
Protein
Mol. Mass.:
83318.87
Organism:
Homo sapiens (Human)
Description:
Q07343
Residue:
736
Sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM50558596
Synonyms:
CHEMBL4791975
Type:
Small organic molecule
Emp. Form.:
C23H20F2N2O4S
Mol. Mass.:
458.478
SMILES:
OC1CCC(CC1)NC(=O)c1csc(n1)-c1ccc(OC(F)F)c2oc3ccccc3c12 |(67.36,-20.14,;66.46,-21.38,;64.93,-21.23,;64.03,-22.47,;64.66,-23.87,;66.19,-24.03,;67.09,-22.79,;63.76,-25.12,;62.23,-24.96,;61.6,-23.56,;61.33,-26.21,;59.78,-26.21,;59.31,-27.69,;60.57,-28.59,;61.81,-27.68,;60.58,-30.13,;59.24,-30.9,;59.24,-32.45,;60.58,-33.22,;60.58,-34.77,;59.25,-35.54,;59.26,-37.08,;57.92,-34.78,;61.91,-32.45,;63.38,-32.92,;64.29,-31.66,;65.82,-31.5,;66.45,-30.09,;65.54,-28.85,;64.01,-29.02,;63.38,-30.42,;61.91,-30.9,)|
Structure:
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