Reaction Details
Report a problem with these data
Report a problem with these dataTarget
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50579900
Substrate
n/a
Meas. Tech.
ChEMBL_2145774 (CHEMBL5030054)
Kd
3.8±n/a nM
Citation
Reutershan, MH; Machacek, MR; Altman, MD; Bogen, S; Cai, M; Cammarano, C; Chen, D; Christopher, M; Cryan, J; Daublain, P; Fradera, X; Geda, P; Goldenblatt, P; Hill, AD; Kemper, RA; Kutilek, V; Li, C; Martinez, M; McCoy, M; Nair, L; Pan, W; Thompson, CF; Scapin, G; Shizuka, M; Spatz, ML; Steinhuebel, D; Sun, B; Voss, ME; Wang, X; Yang, L; Yeh, TC; Dussault, I; Marshall, CG; Trotter, BW Discovery of J Med Chem 64:16213-16241 (2021) [PubMed] Article More Info.:
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
Inhibitor
Name:
BDBM50579900
Synonyms:
CHEMBL5079085
Type:
Small organic molecule
Emp. Form.:
C41H47F6N3O7S
Mol. Mass.:
839.883
SMILES:
CCC[C@H]1N(CCC[C@@]1(Oc1csc(c1)C(F)(F)F)C(=O)N1CCC(O)(CC1)c1ccccc1O[C@H](C)CCC1(CCC1)C(O)=O)C(=O)c1ncccc1C(F)(F)F |r|
Structure:
