Reaction Details Report a problem with these data
Target
Protein arginine N-methyltransferase 6
Ligand
BDBM50580054
Substrate
n/a
Meas. Tech.
ChEMBL_2146523 (CHEMBL5030869)
IC50
388±n/a nM
Citation
 Xiong, B Allosteric Modulation: Dynamics is Double-"E"dged. J Med Chem 64:3694-3696 (2021) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 6
Synonyms:
ANM6_HUMAN | HRMT1L6 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 | Histone-arginine N-methyltransferase PRMT6 | PRMT6 | Protein arginine methyltransferase 6 (PRMT6)
Type:
Protein
Mol. Mass.:
41928.48
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
375
Sequence:
MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED
  
Inhibitor
Name:
BDBM50580054
Synonyms:
CHEMBL5084397
Type:
Small organic molecule
Emp. Form.:
C21H16BrFN2O3
Mol. Mass.:
443.266
SMILES:
Cc1ccc2NC(=O)CN([C@H](c3ccc(F)cc3)c2c1)C(=O)c1ccc(Br)o1 |r|
Structure:
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