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Target
Nuclear receptor subfamily 2 group C member 2
Ligand
BDBM50584720
Substrate
n/a
Meas. Tech.
ChEMBL_2160413 (CHEMBL5045163)
IC50
126±n/a nM
Citation
 Pan, S; Zhang, L; Luo, X; Nan, J; Yang, W; Bin, H; Li, Y; Huang, Q; Wang, T; Pan, Z; Mu, B; Wang, F; Tian, C; Liu, Y; Li, L; Yang, S Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6 J Med Chem 65:2035-2058 (2022) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 2 group C member 2
Synonyms:
NR2C2 | NR2C2_HUMAN | Nuclear receptor subfamily 2 group C member 2 | Nuclear receptor subfamily 2 group C member 2 (TAK1) | TAK1 | TR4
Type:
PROTEIN
Mol. Mass.:
65411.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476357
Residue:
596
Sequence:
MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL
  
Inhibitor
Name:
BDBM50584720
Synonyms:
CHEMBL5088153
Type:
Small organic molecule
Emp. Form.:
C29H31ClN8O3
Mol. Mass.:
575.061
SMILES:
Cc1cc(NC(=O)Nc2cc(nn2-c2ccc(Cl)cc2)C(C)(C)C)ccc1Nc1ncnc2NC(=O)C(C)(C)Oc12
Structure:
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