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Target
Cyclin-C
Ligand
BDBM50248629
Substrate
n/a
Meas. Tech.
ChEMBL_2163626 (CHEMBL5048487)
Kd
2.0±n/a nM
Citation
 Zhang, L; Cheng, C; Li, J; Wang, L; Chumanevich, AA; Porter, DC; Mindich, A; Gorbunova, S; Roninson, IB; Chen, M; McInnes, C A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics. J Med Chem 65:3420-3433 (2022) [PubMed]  Article 
Target
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM50248629
Synonyms:
CHEMBL4076837 | US11471446, Compound DBA-9
Type:
Small organic molecule
Emp. Form.:
C27H26N6O
Mol. Mass.:
450.5349
SMILES:
CN1CCN(CC1)C(=O)c1ccc2cc(CCNc3ncnc4ccc(cc34)C#N)ccc2c1
Structure:
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