Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM50156085
Substrate
n/a
Meas. Tech.
ChEMBL_306405 (CHEMBL828746)
IC50
76±n/a nM
Citation
 Altmann, E; Cowan-Jacob, SW; Missbach, M Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K. J Med Chem 47:5833-6 (2004) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50156085
Synonyms:
6-Cyclohexylamino-9-{2-[(2-methoxy-ethyl)-methyl-amino]-ethyl}-9H-purine-2-carbonitrile | CHEMBL186062
Type:
Small organic molecule
Emp. Form.:
C18H27N7O
Mol. Mass.:
357.4533
SMILES:
COCCN(C)CCn1cnc2c(NC3CCCCC3)nc(nc12)C#N
Structure:
Search PDB for entries with ligand similarity: