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Target
17-beta-hydroxysteroid dehydrogenase type 2
Ligand
BDBM50587609
Substrate
n/a
Meas. Tech.
ChEMBL_2173335 (CHEMBL5058469)
IC50
71±n/a nM
Citation
 Gargano, EM; Mohamed, A; Abdelsamie, AS; Mangiatordi, GF; Drzewiecka, H; Jagodzi?ski, PP; Mazzini, A; van Koppen, CJ; Laschke, MW; Nicolotti, O; Carotti, A; Marchais-Oberwinkler, S; Hartmann, RW; Frotscher, M 17?-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer. ACS Med Chem Lett 12:1920-1924 (2021) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 2
Synonyms:
17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB2_HUMAN | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenas | SDR9C2 | Testosterone 17-beta-dehydrogenase
Type:
Oxidoreductase; single-pass type II membrane protein
Mol. Mass.:
42795.29
Organism:
Homo sapiens (Human)
Description:
Enzyme was partially purified from human placenta.
Residue:
387
Sequence:
MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYDYFAKRHFGQDKPMPRALRMPNYKKKAT
  
Inhibitor
Name:
BDBM50587609
Synonyms:
CHEMBL5090458
Type:
Small organic molecule
Emp. Form.:
C19H15Cl2NO3
Mol. Mass.:
376.233
SMILES:
CN(C(=O)c1ccc(o1)-c1cc(Cl)c(O)c(Cl)c1)c1ccccc1C
Structure:
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