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Target
Adenosine receptor A3
Ligand
BDBM50588460
Substrate
n/a
Meas. Tech.
ChEMBL_2187184 (CHEMBL5099266)
EC50
2754±n/a nM
Citation
 Preti, B; Suchankova, A; Deganutti, G; Leuenberger, M; Barkan, K; Manulak, I; Huang, X; Carvalho, S; Ladds, G; Lochner, M Discovery and Structure-Activity Relationship Studies of Novel Adenosine A J Med Chem 65:14864-14890 (2022) [PubMed] 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50588460
Synonyms:
CHEMBL5187330
Type:
Small organic molecule
Emp. Form.:
C24H30N6O6
Mol. Mass.:
498.5316
SMILES:
CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N[C@@H]3CCC[C@H]3Oc3cccc(OC)c3)ncnc12 |r|
Structure:
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