Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50152799
Substrate
n/a
Meas. Tech.
ChEMBL_303067 (CHEMBL828893)
Ki
6.4±n/a nM
Citation
 Tran, JA; Pontillo, J; Arellano, M; White, NS; Fleck, BA; Marinkovic, D; Tucci, FC; Lanier, M; Nelson, J; Saunders, J; Foster, AC; Chen, C Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylamines. Bioorg Med Chem Lett 15:833-7 (2005) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50152799
Synonyms:
(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[1-(piperidin-3-ylamino)-ethyl]-phenyl}-piperazin-1-yl)-ethyl]-amide | (R)-N-((R)-3-(4-chlorophenyl)-1-oxo-1-(4-(2-(1-(piperidin-3-ylamino)ethyl)phenyl)piperazin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[1-(piperidin-3-ylamino)-ethyl]-phenyl}-piperazin-1-yl)-ethyl]-amide | CHEMBL360716
Type:
Small organic molecule
Emp. Form.:
C36H45ClN6O2
Mol. Mass.:
629.235
SMILES:
CC(NC1CCCNC1)c1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1
Structure:
Search PDB for entries with ligand similarity: