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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50595033
Substrate
n/a
Meas. Tech.
ChEMBL_2215265 (CHEMBL5128397)
IC50
0.400000±n/a nM
Citation
 Wei, J; Wang, J; Zhang, J; Yang, J; Wang, G; Wang, Y Development of inhibitors targeting glycogen synthase kinase-3? for human diseases: Strategies to improve selectivity. Eur J Med Chem 236:0 (2022) [PubMed] 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Human
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50595033
Synonyms:
CHEMBL5175996
Type:
Small organic molecule
Emp. Form.:
C21H13FN2O3
Mol. Mass.:
360.3379
SMILES:
Cn1cc(C2=C(C(=O)NC2=O)c2coc3ccccc23)c2cc(F)ccc12 |t:4|
Structure:
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