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Target
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Ligand
BDBM50176461
Substrate
n/a
Meas. Tech.
ChEMBL_327776 (CHEMBL871142)
IC50
78000±n/a nM
Citation
 Strancar, K; Blanot, D; Gobec, S Design, synthesis and structure-activity relationships of new phosphinate inhibitors of MurD. Bioorg Med Chem Lett 16:343-8 (2005) [PubMed]  Article 
Target
Name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Synonyms:
D-glutamic acid-adding enzyme | MURD_ECOLI | MurD (E. coli) | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase | murD
Type:
Ligase
Mol. Mass.:
46963.02
Organism:
Escherichia coli (strain K12)
Description:
n/a
Residue:
438
Sequence:
MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHLNHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG
  
Inhibitor
Name:
BDBM50176461
Synonyms:
2-(hydroxy-{1-[(R)-2-(4-nitro-phenylmethanesulfonylamino)-propionylamino]-ethyl}-phosphinoylmethyl)-pentanedioic acid | CHEMBL199290
Type:
Small organic molecule
Emp. Form.:
C18H26N3O11PS
Mol. Mass.:
523.451
SMILES:
C[C@@H](NS(=O)(=O)Cc1ccc(cc1)[N+]([O-])=O)C(=O)NC(C)P(O)(=O)CC(CCC(O)=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: