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Target
Histone deacetylase 1
Ligand
BDBM50187080
Substrate
n/a
Meas. Tech.
ChEMBL_383318 (CHEMBL867344)
IC50
4000±n/a nM
Citation
 Moradei, O; Leit, S; Zhou, N; Fréchette, S; Paquin, I; Raeppel, S; Gaudette, F; Bouchain, G; Woo, SH; Vaisburg, A; Fournel, M; Kalita, A; Lu, A; Trachy-Bourget, MC; Yan, PT; Liu, J; Li, Z; Rahil, J; MacLeod, AR; Besterman, JM; Delorme, D Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: novel classes of histone deacetylase inhibitors. Bioorg Med Chem Lett 16:4048-52 (2006) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50187080
Synonyms:
(E)-3-(4-(4-nitrobenzylamino)phenyl)-N-(2-aminophenyl)acrylamide | CHEMBL210122
Type:
Small organic molecule
Emp. Form.:
C22H20N4O3
Mol. Mass.:
388.4192
SMILES:
Nc1ccccc1NC(=O)\C=C\c1ccc(NCc2ccc(cc2)[N+]([O-])=O)cc1
Structure:
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