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Target
Target of rapamycin complex 2 subunit MAPKAP1
Ligand
BDBM50515201
Substrate
n/a
Meas. Tech.
ChEMBL_2261180 (CHEMBL5216191)
IC50
74±n/a nM
Citation
 Oleksak, P; Nepovimova, E; Chrienova, Z; Musilek, K; Patocka, J; Kuca, K Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015-2021). Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
Target of rapamycin complex 2 subunit MAPKAP1
Synonyms:
MAPKAP1 | MIP1 | Mitogen-activated protein kinase 2-associated protein 1 | SAPK-interacting protein 1 | SIN1 | SIN1_HUMAN | Stress-activated map kinase-interacting protein 1 | TORC2 subunit MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 | mSIN1
Type:
PROTEIN
Mol. Mass.:
59129.70
Organism:
Homo sapiens
Description:
ChEMBL_119716
Residue:
522
Sequence:
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGETQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
  
Inhibitor
Name:
BDBM50515201
Synonyms:
CHEMBL4453693
Type:
Small organic molecule
Emp. Form.:
C18H23F2N7O2
Mol. Mass.:
407.4177
SMILES:
C[C@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOCC1 |r|
Structure:
Search PDB for entries with ligand similarity: