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Target
NADPH oxidase 3
Ligand
BDBM318936
Substrate
n/a
Meas. Tech.
ChEMBL_2261582 (CHEMBL5216593)
IC50
1250±n/a nM
Citation
 Shahari, MSB; Dolzhenko, AV A closer look at N Eur J Med Chem 241:0 (2022) [PubMed] 
Target
Name:
NADPH oxidase 3
Synonyms:
1.6.3.- | GP91-3 | MOX-2 | MOX2 | Mitogenic oxidase 2 | NOX3 | NOX3_HUMAN | gp91phox homolog 3
Type:
PROTEIN
Mol. Mass.:
64948.77
Organism:
Homo sapiens
Description:
ChEMBL_104012
Residue:
568
Sequence:
MMGCWILNEGLSTILVLSWLGINFYLFIDTFYWYEEEESFHYTRVILGSTLAWARASALCLNFNCMLILIPVSRNLISFIRGTSICCRGPWRRQLDKNLRFHKLVAYGIAVNATIHIVAHFFNLERYHWSQSEEAQGLLAALSKLGNTPNESYLNPVRTFPTNTTTELLRTIAGVTGLVISLALVLIMTSSTEFIRQASYELFWYTHHVFIVFFLSLAIHGTGRIVRGQTQDSLSLHNITFCRDRYAEWQTVAQCPVPQFSGKEPSAWKWILGPVVLYACERIIRFWRFQQEVVITKVVSHPSGVLELHMKKRGFKMAPGQYILVQCPAISSLEWHPFTLTSAPQEDFFSVHIRAAGDWTAALLEAFGAEGQALQEPWSLPRLAVDGPFGTALTDVFHYPVCVCVAAGIGVTPFAALLKSIWYKCSEAQTPLKLSKVYFYWICRDARAFEWFADLLLSLETRMSEQGKTHFLSYHIFLTGWDENQALHIALHWDENTDVITGLKQKTFYGRPNWNNEFKQIAYNHPSSSIGVFFCGPKALSRTLQKMCHLYSSADPRGVHFYYNKESF
  
Inhibitor
Name:
BDBM318936
Synonyms:
US10173988, Compound A
Type:
Small organic molecule
Emp. Form.:
C23H29N7O
Mol. Mass.:
419.5227
SMILES:
COc1cccc(c1)N1CCN(Cc2nc(N)nc(Nc3ccc(C)c(C)c3)n2)CC1
Structure:
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