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Target
fMet-Leu-Phe receptor
Ligand
BDBM454200
Substrate
n/a
Meas. Tech.
ChEMBL_2275432
EC50
1200±n/a nM
Citation
 Maciuszek, M; Cacace, A; Brennan, E; Godson, C; Chapman, TM Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential. Eur J Med Chem 213:0 (2021) [PubMed] 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Homo sapiens (Human)
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM454200
Synonyms:
US10717708, Example 176 | US11186544, Example 176 | US11530183, Example 176
Type:
Small organic molecule
Emp. Form.:
C26H25ClN4O4
Mol. Mass.:
492.954
SMILES:
COc1ccc(NC(=O)N[C@@H]2CCCN(C2=O)c2ccc(cc2)-c2ccccc2C(N)=O)cc1Cl |r|
Structure:
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