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Target
Dual specificity protein kinase CLK3
Ligand
BDBM50302986
Substrate
n/a
Meas. Tech.
ChEMBL_2277183
IC50
470±n/a nM
Citation
 Qin, Z; Qin, L; Feng, X; Li, Z; Bian, J Development of Cdc2-like Kinase 2 Inhibitors: Achievements and Future Directions. J Med Chem 64:13191-13211 (2021) [PubMed] 
Target
Name:
Dual specificity protein kinase CLK3
Synonyms:
CDC2-like kinase 3 (CLK3) | CLK3 | CLK3_HUMAN | Dual specificity protein kinase CLK3
Type:
Protein
Mol. Mass.:
73570.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
638
Sequence:
MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR
  
Inhibitor
Name:
BDBM50302986
Synonyms:
6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine | CHEMBL567331
Type:
Small organic molecule
Emp. Form.:
C20H15N3O2S
Mol. Mass.:
361.417
SMILES:
C(Nc1ncnc2ccc(cc12)-c1ccc2OCOc2c1)c1cccs1
Structure:
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