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Target
Monocarboxylate transporter 4
Ligand
BDBM21998
Substrate
n/a
Meas. Tech.
ChEMBL_2282174
IC50
>30000±n/a nM
Citation
 Heinrich, T; Sala-Hojman, A; Ferretti, R; Petersson, C; Minguzzi, S; Gondela, A; Ramaswamy, S; Bartosik, A; Czauderna, F; Crowley, L; Wahra, P; Schilke, H; Böpple, P; Dudek, ?; Le?, M; Niedziejko, P; Olech, K; Pawlik, H; W?oszczak, ?; Zuchowicz, K; Suarez Alvarez, JR; Martyka, J; Sitek, E; Mikulski, M; Szcz??niak, J; Jäckel, S; Krier, M; Król, M; Wegener, A; Ga??zowski, M; Nowak, M; Becker, F; Herhaus, C Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology. J Med Chem 64:11904-11933 (2021) [PubMed] 
Target
Name:
Monocarboxylate transporter 4
Synonyms:
MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3
Type:
PROTEIN
Mol. Mass.:
49474.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104604
Residue:
465
Sequence:
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
  
Inhibitor
Name:
BDBM21998
Synonyms:
6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-{[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]carbonyl}-3-methyl-1-(2-methylpropyl)-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione | Thienopyrimidine-2,4-dione, 13
Type:
Small organic molecule
Emp. Form.:
C21H27N5O5S
Mol. Mass.:
461.535
SMILES:
CC(C)Cn1c2sc(Cc3c(C)n[nH]c3C)c(C(=O)N3C[C@H](O)CO3)c2c(=O)n(C)c1=O |r|
Structure:
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