Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50214954
Substrate
n/a
Meas. Tech.
ChEMBL_447647 (CHEMBL896654)
EC50
4100±n/a nM
Citation
 Havranek, M; Sauerberg, P; Mogensen, JP; Kratina, P; Jeppesen, CB; Pettersson, I; Pihera, P Novel selective PPARdelta agonists: optimization of activity by modification of alkynylallylic moiety. Bioorg Med Chem Lett 17:4144-9 (2007) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Human
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50214954
Synonyms:
(Z)-2-(2-methyl-4-(6-phenyl-4-(quinolin-3-yl)hex-2-en-5-ynyloxy)phenoxy)acetic acid | CHEMBL234908
Type:
Small organic molecule
Emp. Form.:
C30H25NO4
Mol. Mass.:
463.5238
SMILES:
Cc1cc(OC\C=C/C(C#Cc2ccccc2)c2cnc3ccccc3c2)ccc1OCC(O)=O |w:8.7|
Structure:
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