Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50222244
Substrate
n/a
Meas. Tech.
ChEMBL_457760 (CHEMBL924037)
IC50
790±n/a nM
Citation
 Xia, M; Hou, C; Pollack, S; Brackley, J; DeMong, D; Pan, M; Singer, M; Matheis, M; Olini, G; Cavender, D; Wachter, M Synthesis and biological evaluation of phenyl piperidine derivatives as CCR2 antagonists. Bioorg Med Chem Lett 17:5964-8 (2007) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50222244
Synonyms:
(E)-3-(3,5-difluorophenyl)-N-(3-((4-(3,4-difluorophenyl)piperidin-1-yl)methyl)cyclopentyl)acrylamide | CHEMBL249811
Type:
Small organic molecule
Emp. Form.:
C26H28F4N2O
Mol. Mass.:
460.5069
SMILES:
Fc1cc(F)cc(\C=C\C(=O)NC2CCC(CN3CCC(CC3)c3ccc(F)c(F)c3)C2)c1 |w:15.15,12.11|
Structure:
Search PDB for entries with ligand similarity: