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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50222991
Substrate
n/a
Meas. Tech.
ChEMBL_458068 (CHEMBL925405)
Ki
266±n/a nM
Citation
 Corbett, JW; Rauckhorst, MR; Qian, F; Hoffman, RL; Knauer, CS; Fitzgerald, LW Heteroatom-linked indanylpyrazines are corticotropin releasing factor type-1 receptor antagonists. Bioorg Med Chem Lett 17:6250-6 (2007) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50222991
Synonyms:
3,6-diethyl-N-((1R,2S)-2-(2-fluoroethoxy)-2,3-dihydro-1H-inden-1-yl)-5-(pyridin-2-yloxy)pyrazin-2-amine | CHEMBL398425
Type:
Small organic molecule
Emp. Form.:
C24H27FN4O2
Mol. Mass.:
422.4952
SMILES:
CCc1nc(Oc2ccccn2)c(CC)nc1N[C@H]1[C@H](Cc2ccccc12)OCCF
Structure:
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